Dr Jon Power

Lecturer

Jon studied at the University of Salford in 1986, graduating in 1989 with a BSc in Biological Sciences. The course included a student exchange programme with a second year placement at the University of Toledo, USA.  He then attended the University of Portsmouth (in collaboration with the National Institute of Medical Research, London) for a PhD in nematode parasitology.

Qualifications

BSc in Biological Sciences

PhD (nematode parasitology)

PG cert HE 

Overview

Following his studies Jon had a switch of fields when he joined the Bone Research Group, Department of Medicine, University of Cambridge in 1996 initially as a laboratory technician specialising in hard tissue histology. The main focus of investigation related to osteoporotic hip fracture. He was promoted to Post-doctoral Research Associate in 2000, remaining in the group till 2011. He then joined the Orthopaedic Research Unit, Department of Surgery, University of Cambridge working on ovine models of joint repair before becoming a lecturer at Chester at the end of 2012.

Interests outside biology include sport (in particular, football, rugby and cricket) and hill walking.

Teaching

BI4112- Cell Biology and Biochemistry

BI4115- Introduction to Biomedical Sciences

BI4114- Data Handling and Project Design

BI5111- Biology of Disease

BI5127- Applied Clinical Skills for Biomedical Sciences

BI6114- Medical Microbiology and Infection Control

BI6128- Cellular and Molecular Pathology

BI6170- Animal Parasitism: Medical, Veterinary and Ecological Aspects

BI6110 – BSc Dissertation

Programme leader for Health Care Sciences Foundation Degree

Research

Main interests include:

  • In situ analysis of bone loss associated with femoral neck fracture in the elderly
  • Investigation of an Ovine model of skeletal under-loading
  • Osteocytes as regulators of bone remodelling
  • The role of osteocytic sclerostin (inhibitor of bone formation) in fracture repair
  • Analysis of joint repair mechanisms in ovine models
  • Helminth Parasitology

 

Image below shows the localisation of sclerostin using immunohistochemical staining in the fractured human femoral neck. (The fracture zone is indicated by the arrows). Sclerostin expression within osteocytes is reduced close to the fracture site. This observation of reduced sclerostin, a known inhibitor of bone formation in close proximity to the fracture, is suggestive of an induction of bone repair.

Dr Jon Power: Localisation of sclerostin using immunohistochemical  staining in the fractured human femoral neck. (The fracture zone is indicated by the arrows). Sclerostin expression within osteocytes is reduced  close to the fracture site. This observation of reduced

Published work

Hopper, N., Wardale, J., Brooks, R., Power, J., Rushton, N., & Henson, F. (2015). Peripheral blood mononuclear cells enhance cartilage repair in in vivo osteochondral defect model. PloS one, 10(8), e0133937. 

Power J, Hernandez P, Guehring H, Getgood A, Henson F. Intra-articular injection of rhFGF-18 improves the healing in microfracture treated chondral defects in an ovine model. J Orthop Res. 2014 May;32(5):669-76. doi: 10.1002/jor.22580. Epub 2014 Jan 16 

Power J, Taggart J, Parker M, Berry JL, Reeve J. Bone marrow levels of 25 hydroxy vitamin D are not depressed in cases of hip fracture compared with controls. Cell Biochem Funct. 2014 Jun;32(4):341-3. doi: 10.1002/cbf.3021. Epub 2013 Dec 27. 

Power J, Doube M, van Bezooijen RL, Loveridge N, Reeve J. Osteocyte recruitment declines as the osteon fills in: interacting effects of osteocytic sclerostin and previous hip fracture on the size of cortical canals in the femoral neck. Bone. 2012 May;50(5):1107-14. doi: 10.1016/j.bone.2012.01.016. Epub 2012 Jan 28. 

van Lierop AH, Hamdy NA, Hamersma H, van Bezooijen RL, Power J, Loveridge N, Papapoulos SE. Patients with sclerosteosis and disease carriers: human models of the effect of sclerostin on bone turnover. J Bone Miner Res. 2011 Dec;26(12):2804-11. 

Power J, Poole KE, van Bezooijen R, Doube M, Caballero-Alías AM, Lowik C, Papapoulos S, Reeve J, Loveridge N. Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture.  J Bone Miner Res. 2010 Aug;25(8):1867-76.

Thomas CD, Mayhew PM, Power J, Poole KE, Loveridge N, Clement JG, Burgoyne CJ, Reeve J.  Femoral neck trabecular bone: loss with aging and role in preventing fracture.  J Bone Miner Res. 2009 Nov;24(11):1808-18.

Poole KE, Vedi S, Debiram I, Rose C, Power J, Loveridge N, Warburton EA, Reeve J, Compston J.  Bone structure and remodelling in stroke patients: early effects of zoledronate.  Bone. 2009 Apr;44(4):629-33. Epub 2008 Dec 11

Power, J., Loveridge, N., Lyon, A., Rushton, N., Parker, M., and Reeve, J. Osteoclastic cortical erosion as a determinant of sub-periosteal osteoblastic bone formation in the femoral neck’s response to BMU imbalance. Effects of stance-related loading and hip fracture.  Osteoporos Int. 2005 Sep;16(9):1049-56.

Loveridge, N., Power, J., Reeve, J and Boyde, A. Bone mineralization density and femoral neck fragility.  Bone; 35 929-941: 2004.

Mayhew, P., Kaptoge, S., Loveridge, N., Power, J., Kroger, HP., Parker, M and Reeve, J. Discrimination between cases of hip fracture and controls is improved by hip structural analysis compared to areal bone mineral density. An ex vivo study of the femoral neck. Bone; 34 (2) 352-61: 2004.

Power, J., Loveridge, N., Lyon, A., Rushton, N., Parker, M., and Reeve, J. Bone Remodelling at the Endocortical Surface of the Human Femoral Neck: A Mechanism for Regional Cortical Thinning in Cases of Hip Fracture.  Journal of Bone and Mineral Research; 18(10) 1775-1780: 2003. 

Power, J, Loveridge, N., Rushton, N., Parker M and Reeve, J. Evidence for Bone Formation on the External 'Periosteal' Surface of the Femoral Neck:  A Comparison of Intracapsular Hip Fracture Cases and Controls.  Osteoporosis International; 14 141-145: 2003.

Jordan, G.R., Loveridge, N., Power, J., Clarke, M.T and Reeve, J. Increased cancellous bone in the femoral neck of patients with coxarthrosis (hip osteoarthritis): a positive remodeling imbalance favoring bone formation Osteoporosis International;14(2)160-5: 2003.                      

Jordan, G.R., Loveridge, N., Bell ,K.L., Power, J., Dickson, G.R., Vedi, S., Rushton, N., Clarke, M.T and Reeve, J. Increased femoral neck cancellous bone and connectivity in coxarthrosis (hip osteoarthritis) Bone; 32(1) 86-95: 2003.

Jordan, G.R., Loveridge, N., Power, J., Clarke, M.T., Parker, M. and Reeve, J. The ratio of osteocytic incorporation to bone matrix formation in femoral neck cancellous bone: an enhanced osteoblast work rate in the vicinity of hip osteoarthritis. Calcified Tissue International; 72(3) 190-6: 2003.

Loveridge N, Fletcher S, Power J, Caballero-Alías AM, Das-Gupta V, Rushton N, Parker M, Reeve J, Pitsillides AA.

Patterns of osteocytic endothelial nitric oxide synthase expression in the femoral neck cortex: differences between cases of intracapsular hip fracture and controls. Bone. 2002 Jun;30(6):866-71.

Power, J., Loveridge, N., Rushton, N., Parker M and Reeve, J.  Osteocyte density in aging subjects is enhanced in bone adjacent to remodeling Haversian systems. Bone; 30 (6) 859-865: 2002.

Power, J, Noble, B. S., Loveridge, N., Bell, K. L., Rushton, N. and Reeve, J.  Osteocyte lacunar occupancy in the femoral neck cortex : An association with cortical remodeling in hip fracture cases and controls. Calcified Tissue International; 69(1) 13-19: 2001.

Crabtree N., Loveridge N., Parker M., Rushton N., Power J., Bell KL., Beck TJ., Reeve J. Intracapsular hip fracture and the region-specific loss of cortical bone: analysis by peripheral quantitative computed tomography. Journal of Bone and Mineral Research; 16(7)1318-28: 2001.

Jordan, G. R., Loveridge, N., Bell, K. L., Power, J., Rushton, N. and Reeve, J.  Spatial clustering of remodeling osteons in the femoral neck cortex: A cause of weakness in hip fracture? Bone;  26:305-313; 2000.

Bell, K. L., Loveridge, N., Jordan, G., Power, J. and Reeve, J.  Osteonal remodelling and focal weakening of the femoral neck cortex. Journal of Bone and Mineral Research; 15:52: 2000.

Bell, K. L., Loveridge, N., Jordan, G. R., Power, J., Constant, C. R. and Reeve, J.  A novel mechanism for induction of increased cortical porosity in cases of intracapsular hip fracture. Bone;  27:297-304: 2000.

Bell, K. L., Loveridge, N., Power, J., Rushton, N. and Reeve, J.  Intracapsular hip fracture: Increased cortical remodeling in the thinned and porous anterior region of the femoral neck. Osteoporosis International; 10:248-257: 1999.

Bell, K. L., Loveridge, N., Power, J., Garrahan, N., Stanton, M., Lunt, M., Meggitt, B. F. and Reeve, J.  Structure of the femoral neck in hip fracture: Cortical bone loss in the inferoanterior to superoposterior axis. Journal of Bone and Mineral Research; 14:111-119: 1999.

Bell, K. L., Loveridge, N., Power, J., Garrahan, N., Meggitt, B. F. and Reeve, J.  Regional differences in cortical porosity in the fractured femoral neck. Bone; 24:57-64: 1999.

Power, J., Harnett, W. and Jenkins, T.  Characterisation of the surface polypeptides of Strongyloides ratti; A comparison of homogonic and heterogonic strains. Helminthology; 68 (1) 57-62: 1994.