Qualifications
BSc (Hons), PgCert, MPhil, PhD
Overview
Stephen studied initially at Cardiff where he gained his BSc (Hons) in Biomedical Science, followed by an MPhil. He subsequently gained his PhD from the University of Keele (Institute for Science & Technology in Medicine). Stephen is employed by the University of Chester as a Senior Lecturer and Programme Leader BSc (Hons) Biomedical Science. His main teaching subjects include Haematology, Immunology, Blood Transfusion Medicine and Research Methods. Prior to this he was employed by the University of Hertfordshire as a Senior Lecturer in Biomedical Science. He has worked as a Biomedical Scientist/Researcher at the North Wales (Central) NHS Trust and as a Senior Biomedical Scientist/Pathology Manager at the North Wales Medical Centre.
Stephen is a Fellow member of the Institute of Biomedical Science (IBMS), a Charted Scientist (CSci) affiliated with the Science Council, and is a registered Biomedical Scientist affiliated with the Health Professions Council (HPC). He is also a Fellow member of the Higher Education Academy (FHEA), is a specialist portfolio examiner for the IBMS, an external examiner for Nottingham Trent University, and is a member of the University of Chester careers committee.
Outside of work, Stephen was once a keen footballer and has represented Wales in football at Schoolboy and College level. He is a qualified football coach associated with the Football Association of Wales. Other activities he enjoys are playing golf, rugby union, walking the Snowdonia National Park and visiting art galleries and museums with his friends and family.
Professional Membership
- Charted Scientist affiliated with the Science Council (CSci)
- Fellow Member of the Institute of Biomedical Science (FIBMS)
- Registered Biomedical Scientist affiliated with the Health Professions Council (HPC)
- Fellow Member of the Higher Education Academy (FHEA)
- Member of the British Orthopaedic Research Society (BORS)
- Member of the British Society for Immunology (BSI)
Teaching
Modules:
- BI4115 – Introduction to Biomedical Sciences (U)
- BI4933 – Haematology & Immunology (BL)
- BI4934 – The Health Care Scientist & Patient Care (BL)
- BI5934 – Transfusion Science (BL)
- BI5930 – Research Methods & Medical Ethics (BL)
- BI5113 – Experiential Learning (U)
- BI6115 – Immunology & Haematology (U)
- BI6113 – Clinical Medicine & Pharmacology (U)
- BI6110 – Dissertation (U)
- BI6159 – Clinical Medicine & Pharmacology (BL)
- BI6161 – Immunology & Haematology (BL)
- BI7106 – Current Issues in Biomedical Science (PG)
- BI7107 – Clinical Immunology & Microbial Pathogenesis (PG)
- BI7108 – Blood Sciences (PG)
- BI7112 – Dissertation (PG)
BL – Blended Learning, U – undergraduate, PG - Postgraduate
Research
I have been active in the field of biomedical research since 1999. My initial research interests involved investigating the role of phagocytic leukocytes during ischaemia-reperfusion injury. Ischaemia is the reduction of blood supply to a part of the body and reperfusion occurs when blood flow is re-established. This process occurs during various pathological disorders such as ischaemic heart disease (IHD), peripheral vascular disease and stroke, and during various surgical procedures that involve the application of a tourniquet (e.g. cardio-aortic surgery and various orthopaedic surgeries).
Current research interests are to investigate the effects of total hip and total knee replacement orthopaedic surgery on various biological markers, leukocyte and endothelial function and various clinical outcome measures (such as post-operative pain, pyrexia and oedema). Orthopaedic surgery is the branch of medicine concerned with acute, chronic, traumatic, recurrent injuries and other disorders of the musculoskeletal system. Apart from the mechanical considerations, it is also concerned with the pathology, genetics, intrinsic, extrinsic, and biomechanical factors involved.
Promoting research in this field will develop a better understanding of the musculoskeletal disorders, where the incidence of such diseases and subsequent surgery is high in the United Kingdom. Minor improvements in the treatment may therefore generate guidelines for quality of care issues during such circumstances, thus promoting good practice for treatment, and possibly having cost benefits for the NHS and health benefits for the nation.
Specifically, my current research interests are divided into the following areas:
Clinical
- Orthopaedic Surgery (upper and lower limb)
- Rheumatoid Arthritis
- Osteoarthritis
- Osteoporosis
- Clinical outcome measures (e.g. pyrexia) and their relationship with biological markers
Scientific
- Leukocyte biology
- The leukocyte adhesion cascade
- Adhesion molecules
- Biological markers
Published work
Hughes SF, Hendricks BD, Edwards DR, Middleton JF, (2010). Tourniquet-Applied Upper Limb Orthopaedic Surgery Results in Increased Inflammation and Changes to Leukocyte, Coagulation and Endothelial Markers. PLoS ONE 5(7): e11846. doi:10.1371/journal.pone.0011846.
Stephen F Hughes, Beverly D Hendricks, David R Edwards, Kirsty M Maclean, Salah S Bastawrous, Jim F Middleton (2010). Total hip and knee replacement surgery results in changes in leukocyte and endothelial markers. Journal of Inflammation [Lond.] 7(2).
S F Hughes, B D Hendricks, D R Edwards, K M Maclean, J F Middleton (2009). Total hip and knee replacement orthopaedic surgery results in leukocyte and endothelial activation and changes in inflammatory markers. British Orthopaedic Research Society (BORS). (Br) Journal of Bone and Joint Surgery [Abstract].
Hughes S.F., Hendricks B.D., Edwards D.R., Bastawrous S.S., Roberts G. & Middleton J.F. (2007). Mild episodes of tourniquet-induced forearm ischaemia-reperfusion injury results in leukocyte activation and changes in inflammatory and coagulation markers. Journal of Inflammation [Lond.] 4(1): 12.
S. F. Hughes, M. J. Cotter, S-A. Evans, K. P. Jones, R. A. Adams (2006). The role of leukocytes in damage to the vascular endothelium during ischaemia-reperfusion injury. Br J Biomed Sci 2006; 63(4); 166-170.
S F Hughes, B D Hendricks, S S Bastawrous, D R Edwards, J F Middleton (2006). The effects of Phorbol Myristate Acetate (PMA) and N-Formyl-Met-Leu-Phe (fMLP) on leucocyte adhesion and activation. British Orthopaedic Research Society (BORS). (Br) Journal of Bone and Joint Surgery. Vol 90-B, Issue SUPP II, 393. [Abstract].
S. F. Hughes, S-A. Evans, K. P. Jones and R. Adams (2005). The effect of tourniquet induced ischaemia-reperfusion injury on leukocyte adhesion and trapping. British Orthopaedic Research Society (BORS). Journal of Bone and Joint Surgery (Br) Vol 88-B, Issue SUPP III, 408-409. [Abstract].
Hughes, S. (2001). The role of leucocytes in ischaemia - reperfusion injury. UWIC ‘Concord’ Special Issue. Volume 10 (Number 1): 33-41.
