Dr Stephen Fôn Hughes

Senior Lecturer & Programme Leader BSc (Hons) Biomedical Science; Director North Wales & North West Urological Research Centre (NW2URC); Betsi Cadwaladr University Hospital (BCUHB) Honorary Research Fellow; Registered Biomedical Scientist

Stephen joined the Department of Biological Sciences at the University of Chester as a Senior Lecturer & Programme Leader BSc (Hons) Biomedical Science in June 2008.

Qualifications

BSc (Hons), PgCert, MPhil, PhD

Overview

Since June 2008, Stephen has been employed by the University of Chester as a Senior Lecturer and Programme Leader BSc (Hons) Biomedical Science. Stephen’s main teaching subjects include Haematology and Blood Transfusion Science. 

Stephen is a Fellow member of the Institute of Biomedical Science (IBMS), a Chartered Scientist (CSci) affiliated with the Science Council, and the University of Chester’s sole registered Biomedical Scientist affiliated with the Health & Care Professions Council (HCPC). Previously, Stephen has worked as a registered Biomedical Scientist (Haematology with Hospital Transfusion Practice) for the NHS, and as Senior Biomedical Scientist and Pathology Manager at the North Wales Medical Centre. 

In January 2014, Stephen established the North Wales & North West Urological Research Centre (NW2URC) with Co-Director, Mr Iqbal Shergill (Consultant Urological Surgeon). During this time he was awarded the title of Honorary Research Fellow by Betsi Cadwaladr University hospital (BCUHB). This research centre is the main vehicle for Stephen’s current research work, which primarily involves investigating patients with benign or malignant disorders of the kidneys, bladder and prostate.

Amongst Stephen’s various external activities, he is a specialist portfolio examiner (haematology with hospital transfusion practice) for the IBMS. This role involves assessing the suitability of hospital based practitioners to practice at a Senior/Managerial level. Stephen is an IBMS accreditation panel member, where his role enables him to identify and implement curriculum change to programmes at other Higher Education Institutions (HEIs). Stephen is also a member and deputy-chief examiner of the national IBMS Transfusion Science advisory panel.

By invitation, Stephen is currently an external examiner for Keele University, having previously performed a similar role at Nottingham Trent University and the University of Wolverhampton. Stephen is also a Fellow member of the Higher Education Academy (FHEA), and has acted as an internal and external examiner for several PhDs (viva voce).

Outside of work, Stephen was once a keen footballer and has represented Wales in football at Schoolboy and College level. He still enjoys playing football for Gresford in the Cheshire Veterans (over 35s) league, and is a keen Manchester United supporter. Other activities he enjoys are playing golf and walking the picturesque beaches of Anglesey, North Wales.

Aberffraw beach, Anglesey.

Professional Membership

  • Fellow of the Institute of Biomedical Science (FIBMS: 375856)
  • Chartered Scientist (CSci) affiliated with the Science Council (BMS:109004196)
  • Fellow of the Higher Education Academy (FHEA: 35751)
  • Registered Biomedical Scientist affiliated with the Health & Care Professions Council (HCPC number: BS41370: 1998 to Date)

Teaching

  • BI4115 – Introduction to Biomedical Sciences
  • BI5111 – Biology of Disease
  • BI5127 – Applied Clinical Skills for Biomedical Sciences
  • BI5934 – Transfusion Science
  • BI6110 – Dissertation
  • BI6125 – Blood Sciences 

Research

Research Group

The North Wales and North West Urological Research Centre (NW2URC) was established by Dr Stephen Fôn Hughes and Mr Iqbal Shergill (Consultant Urological Surgeon, Wrexham Maelor Hospital) in January 2014.

Collaboration between the Betsi Cadwaladr University Health Board (BCUHB), Department of Urology, Wrexham Maelor Hospital, North Wales, and the Department of Biological Sciences, University of Chester has provided the opportunity to develop, undertake and promote urological research in the area. NW2URC have a research laboratory based at Wrexham Maelor Hospital, North Wales. Here, postgraduate (PG) research students (clinicians and scientists) undertake their research involving urological patients. 

NW2URC research laboratory

NW2URC research laboratory based at Wrexham Maelor Hospital, North Wales 

Recently, NW2URC has established collaboration with Mr Manit Arya and his medical team at the Department of Urology, University College London Hospitals, and Dr Ian Barwick and his team at Life Sciences Hub Wales. Collaboration between BCUHB, UCHL, Life Sciences Hub Wales and the University of Chester will enhance research links between these establishments and promote medical research in the area and nationally.

Twitter: @NW2URC

Overview of Research

The number of patients in the UK having surgical interventions for the treatment of benign and malignant disorders of the kidneys, prostate, and bladder is increasing annually. As such, there have been an increasing number of patients developing disease recurrence and progression, as well as post-operative complications (e.g. infection and blood clots).

Research & Innovation meeting with Welsh Health Minister

Research & Innovation meeting with
Welsh Health Minister: Vaughan Gething (centre), July 2016 

 

Post-operative complications result in patients requiring longer hospital stays, poor patient experience and outcomes, as well as carrying additional financial constraints for the healthcare provider (NHS). Minor improvements in the monitoring of these patients following treatment could possibly have financial benefits for the healthcare provider and health benefits for the nation.

Specifically, our current research interests are divided into the following areas: 

Clinical

  • Kidney stones and kidney cancer
  • Bladder cancer
  • Benign and malignant disorders of the prostate
  • Clinical outcome measures (e.g. acute kidney injury, infection, bleeding, oedema, blood clots) and their relationship with biological markers

Scientific

  • Leukocyte biology
  • Vascular endothelium
  • Inflammation
  • Cytokines & adhesion molecules
  • Biomarkers

Early indications are that our studies may lead to important intervention relating to both treatment and diagnosis in these patients. Currently only simple non-specific blood tests are available to predict clinical outcomes and post-operative complications. No biomarker profiles are available to forecast with confidence, post- operative complications or to predict cancer recurrence and progression. Our aim therefore, is to establish such profiles. 

The North Wales & North West Urological Research Centre (NW2URC) team

The North Wales & North West Urological Research Centre (NW2URC) team at the British Association of Urological Surgeons (BAUS) Conference, Liverpool (August 2016).(Left to Right: Mr Peter Ella-Tongwiis (PhD student); Dr Stephen Fôn Hughes; Mr Iqbal Shergill; Ms Alyson Jayne Moyes (PhD student); Ms Rebecca May Lamb (PhD student) 

Specifically, patients with cancer and benign conditions of the kidney, bladder and prostate will benefit as a result of increased ability in detecting recurrence and progression, allowing stricter surveillance follow-up programmes. Our research study promises to help patients (regionally and nationally) who have been diagnosed with various urological disorders, and will ultimately allow current NHS post-operative care protocols to be revised and improved; thus improving the patients’ health and well-being.

Postgraduate (PG) Research Students

  • Alyson Moyes (PhD) – Kidney Stones (lead supervisor)
  • Peter Ella-Tongwiis (PhD) – Bladder Cancer (lead supervisor)
  • Rebecca May Lamb (PhD) – Bladder Cancer (lead supervisor)
  • Jonty Norris (PhD) – Applied physiology of rugby league (joint supervisor)
  • Tarimoboere Agbalalah (PhD) – Vitamin D & Cardiovascular Disease (joint supervisor)
  • Max Lister (MPhil) – Bone Remodelling (joint supervisor)

 Self-funded MRes, MPhil/PhD projects available:

  • Bladder Cancer (MRes, MPhil/ PhD)
  • Prostate Cancer (MPhil/PhD)
  • Kidney Stones (MRes, MPhil/PhD)
  • Effect of storage on erythrocyte, leukocyte, and thrombocyte function (MRes)
  • Role of phagocytic leukocytes during Ischaemia & Reperfusion Injury (MRes)

              *A small bursary may be available for some of the projects listed

For further enquiries, please email me.

Published work

Tari Agbalalah, Stephen F. Hughes, Ellen J. Freeborn, Sohail Mushtaq (2017). Impact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review, Journal of Steroid Biochemistry and Molecular Biology http://dx.doi.org/10.1016/j.jsbmb.

Jacob A. Mear& Stephen F. Hughes (2017). The Effect of Phorbol 12-Myristate 13-Acetate on CD11b and CD62-L Cell Surface Expression of Neutrophils and Monocytes. International Journal of Biochemistry Research & Review. DOI: 10.9734/IJBCRR/2016/30998.

Peter Ella-Tongwiis & Stephen Fôn Hughes (2016). The Effect of Storage on Various Haematological and Biochemical Parameters of NHSBT Donor Blood. J J Hemato., 2(2): 029. 

Stephen F. Hughes (2016). Urological Research: A profile of the NW2URCThe Biomedical Scientist, Aug. Ed., p418. 

Jonathan P. Norris, Jamie Highton, Stephen F. Hughes & Craig Twist (2016): The effects of physical contact type on the internal and external demands during a rugby league match simulation protocol. Journal of Sports Sciences, DOI: 10.1080/02640414.2016.1140907. 

S.F. Hughes, S.J. Thomas-Wright, J. Banwell, S. Mushtaq, R. Williams, M. Abdulmajed, I. Shergill (2015). A Pilot Study to Evaluate Haemostatic Function, following Shock Wave Lithotripsy (SWL) for the Treatment of Solitary Kidney Stones. PLOS ONE. DOI: 10.1371/journal.pone.0125840.

K.L. Dudley, S. Rides, A.K. Banerjee and S.F. Hughes (2014). Leukocyte, haemostatic and inflammatory biomarkers are activated in patients with cardiovascular disease (CVD): A Pilot Study British Journal of Medicine & Medical Research4(26): 4392-4406.

Rebecca J. Edge1, Peter Ella-Tongwiis, Robert C. Coleman and Stephen F. Hughes (2014). Mild-Tourniquet Induced Ischaemia-reperfusion Injury Results in Changes to Haematological, Haemostatic and Inflammatory Parameters. British Journal of Medicine & Medical Research4(13): 2470-2482.

Hughes S.F., Thomas-Wright S.J., Banwell J., Mushtaq S., Williams R., Abdulmajed M., Shergill I. (2014). Are urological patients at increased risks of developing haemostatic complications following shock wave lithotripsy (SWL) for solitary unilateral kidney stones? European Urology Supplements. Vol13 (1), e816. doi:10.1016/S1569-9056(14)60804-6.  

Stephen F Hughes, Beverly D Hendricks, David R Edwards, Salah S Bastawrous and Jim F Middleton5 (2013). Lower limb orthopaedic surgery results in changes to coagulation and non-specific inflammatory biomarkers, including selective clinical outcome measures. European Journal of Medical Research; 18:40 doi:10.1186/2047-783X-18-40.

J.R. Bannister, A.L. Khan, D.W. Eccleston, & S.F. Hughes (2012). Interleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequence. Journal of Inflammation [Volume 2012 (2012), Article ID 578149, 6 pagesdoi:10.5402/2012/578149].

Hughes SF, Hendricks BD, Edwards DR, & Middleton JF, (2010). Tourniquet-applied upper limb orthopaedic surgery results in increased inflammation and changes to leukocyte, coagulation & endothelial markers. PLOS ONE 5(7): e11846. doi:10.1371/journal.pone.0011846.

Stephen F. Hughes, Beverly D. Hendricks, David R. Edwards, Kirsty M. Maclean, Salah S. Bastawrous, & Jim F. Middleton (2010). Total hip and knee replacement surgery results in changes in leukocyte and endothelial markers. Journal of Inflammation [Lond.] 7(2) doi:10.1186/1476-9255-7-2.

Stephen Hughes, Beverly Hendricks, David Edwards, Kirsty Maclean, Jim Middleton (2010). Tourniquet-applied upper limb orthopaedic surgery results in changes to various inflammatory parameters. Inflamm. Res. 59 (Suppl 1):S1–S8. DOI 10.1007/s00011-010-0169-5.

Hughes, S., Hendricks, B., Bastawrous, S., Edwards, D., & Middleton, J. (2008). The effects of phorbol myristate acetate (PMA) and n-formyl-met-leu-phe (fMLP) on leucocyte adhesion and activation. Orthopaedic Proceedings, 90-B (SUPP II), 393.

Hughes S.F., Hendricks B.D., Edwards D.R., Bastawrous S.S., Roberts G. & Middleton J.F. (2007). Mild episodes of tourniquet-induced forearm ischaemia-reperfusion injury results in leukocyte activation and changes in inflammatory and coagulation markers. Journal of Inflammation [Lond.] 4(1): 12 doi:10.1186/1476-9255-4-12.

S. F. Hughes, M. J. Cotter, S-A. Evans, K. P. Jones, R. A. Adams (2006). The role of leukocytes in damage to the vascular endothelium during ischaemia-reperfusion injury. Br J Biomed Sci.; 63(4); 166-170.

Hughes, S. F., Evans, S., Jones, K. P., & Adams, R. (2006). The effect of tourniquet induced forearm ischaemia-reperfusion injury on leukocyte adhesion and trapping. Orthopaedic Proceedings, 88-B (SUPP III), 408-409.

Conferences Proceedings (since 2010)

Oral and poster presentations

SF Hughes, AJ Moyes, RM Lamb, J Mear, PE-Tongwiis, A Pushkaran, I Ahmed, V Stainer & I Shergill (2017). A pilot study evaluating the changes to haematological and biochemical tests after Flexible Ureterorenoscopy for the treatment of kidney stonesBritish Association of Urological Surgeons (BAUS) Academic Conference, London. January, 2017. POSTER

Rebecca Lamb, Peter Ella-Tongwiis, Alyson Moyes, Anish Pushkaran, Issam Ahmed, Victoria Stainer, Iqbal Shergill, & Stephen F. Hughes (2016). Changes in routine, cellular & molecular biomarkers following Transurethral Resection of a Bladder Tumour (TURBT) for Non-Muscle Invasive Bladder Cancer (NMIBC): A pilot study. Welsh Urological Society & Welsh Surgical Society Conference (joint meeting), London. November 2016. POSTER

SF. Hughes, A. Moyes, P. E-Tongwiis, R. Lamb, & I. Shergill (2016). North Wales & North West Urological Research Centre: Kidney stones and bladder cancer research. British Association of Urological Surgeons (BAUS) Conference, Liverpool. August, 2016. POSTER

SF. Hughes (2016). North Wales & North West Urological Research Centre: An innovative approach to research and collaborative working. MediWales NHS Collaboration Conference, Cardiff. July, 2016. PODIUM (keynote speaker)

SF. Hughes (2015). The North Wales & North West Urological Research Centre. Welsh Urology Society (WUS) Conference, Wrexham, North Wales. April, 2015. PODIUM (keynote speaker)

M. Abdulmajed, S.J. Thomas-Wright, J. Banwell, S. Mushtaq, R. Williams, I. Shergill & S.F. Hughes (2015). A pilot study to evaluate haemostatic function, following shock wave lithotripsy (SWL) for the treatment of solitary kidney stones. 13th Annual Norman Gibbon Academic Urology Meeting, Liverpool. February, 2015. PODIUM

Alyson Moyes, Iqbal Shergill, Samantha J. T-Wright, Joseph Banwell, Sohail Mushtaq, Mohamed Abdulmajed & Stephen F. Hughes (2014). Shock wave lithotripsy (SWL), for the treatment of solitary unilateral kidney stones, results in changes to inflammatory and phagocytic leucocyte biomarkers. British Association of Urological Surgeons (BAUS) Academic Conference London. December, 2014. POSTER

S.F. Hughes, S.J. Thomas-Wright, J. Banwell, S. Mushtaq, R. Williams, M. Abdulmajed, I. Shergill (2014). Are urological patients at increased risks of developing haemostatic complications following shock wave lithotripsy (SWL) for solitary unilateral kidney stones? 29th Annual European Association of Urology Congress, Stockholm, Sweden. April, 2014. PODIUM

Hughes, S.F. (2013)Lower limb orthopaedic surgery results in changes to selective biomarkers. University of Malta, Faculty of Medicine 20th Anniversary Biomedical Science Congress, Malta. March, 2013. PODIUM (keynote speaker)

Hughes, SF (2011)The inflammatory response following various orthopaedic surgeries. Indian Institute of Technology (IIT), Delhi, India. February, 2011. PODIUM

Hughes, SF (2011)Tourniquet-Applied Upper Limb Orthopaedic Surgery Results in Increased Inflammation and Changes to Leukocyte, Coagulation and Endothelial Markers. Kempegowda Institute of Medical Sciences (KIMS), Bangalore, India. February, 2011. PODIUM

Hughes, SF (2010)Tourniquet-applied upper limb orthopaedic surgery results in changes to various inflammatory parameters. 8th World Congress - Trauma, Shock, Inflammation & Sepsis (TSIS), Munich, Germany. March, 2010. PODIUM