Dr Elyse Ireland

Senior Lecturer/Researcher

Elyse Ireland is a senior lecturer/researcher with over 18 years’ experience within academic research on a wide variety of areas, covering environmental plant biology, analysis of food additives and speciation of dairy products.

Qualifications

BSc, PhD

Overview

I have over 18 years’ experience in academic research/teaching as well as consultancy in biomedical and food related areas, but now specialise in immunology, specifically inflammation and cancer. I received both my BSc and PhD from the University of Liverpool whilst working full-time and have published scientific articles in a wide variety of subject areas including, inflammation, forensics, food speciation, and human and plant biomarkers. In 2010, I was awarded one of the A. E. Baue awards at the prestigious 8th World Congress on Trauma, Shock, Inflammation and Sepsis (TSIS2010) in Munich for one of the top ten peer reviewed science projects presented during TSIS 2010.

Teaching

I teach on a number of modules at both undergraduate and postgraduate levels. I am a fellow member of the Institute of Biomedical Sciences (FIBMS); member of both the British and European Societies for Immunology (BSI/ESI); and a current member of the Faculty of Applied Sciences Research Ethics Committee.

Research

My current research interests are within the area of inflammation and modulation of immune responses, particularly in relation to monocyte/macrophage plasticity.  I am actively involved in knowledge transfer and project management, and am currently working with a number of international scientific companies.

Published work

Ireland, H.E. & Williams, J.H.H. (2011). Measuring Hsp72 (HSPA1A) by indirect sandwich ELISA. In: Calderwood, S.K. (Ed.): Heat Shock Proteins: Methods & Protocols, (Book Series: Methods in Molecular Biology. Humana Press Inc. Totowa, USA.

Dempsey, N.C., Ireland, H.E., Smith, C.M., Hoyle, C.F. & Williams, J.H.H. (2010). Heat Shock Protein translocation induced by membrane fluidization increases tumor-cell sensitivity to chemotherapeutic drugs. Cancer Letters, 296 (2): 257-267.

Hurley, I.P., Pickles, N.A., Qin, H., Ireland, H.E., Coleman, R., Tosun, B.N., Buyuktuncer, Z. & Williams, J.H.H. (2010). Detection of Konjac glucomannan by immunoassay. International Journal of Food Science and Technology, 45 (7): 1410-1416.

Dempsey, N.C., Leoni, F., Ireland, H.E., Hoyle, C. & Williams, J.H.H. (2010). Differential heat shock protein localization in Chronic Lymphocytic Leukaemia. Journal of Leukocyte Biology, 87 (3): 467-476.

Hurley, I.P., Cook, R., Laughton, C.W., Pickles, N.A., Ireland, H.E. & Williams, J.H.H. (2009). Detection of human blood by immunoassay for applications in forensic analysis. Forensic Science International, 190: 91-97.

Williams, J.H.H & Ireland, H.E. (2008). Sensing danger - Hsp72 and HMGB1 as candidate signals. Journal of Leukocyte Biology, 83: 489-492.

Ireland, H.E., Leoni, F., Altaie, O., Birch, C.S., Coleman, R.C., Hunter-Lavin, C. & Williams, J.H.H. (2007). Measuring the secretion of heat shock proteins from cells. Methods, 43: 176-183.

Pickles, N.A., Aoki, H., Al-Assaf, S., Sakata, M., Ogasawara, T., Ireland, H.E., Coleman, R.C., Phillips, G.O. & Williams, J.H.H. (2007). Characterisation and properties of Acacia senegal (L.) Willd. Var, senegal with enhanced properties (Acacia (sen) SUPER GUM™): part 3 Immunological characterisation of Acacia (sen) SUPER GUM™. Food Hydrocolloids, 21: 338-346.

Hurley, I.P., Coleman, R.C., Ireland, H.E. & Williams, J.H.H. (2006). Use of sandwich IgG ELISA for the detection and quantification of adulteration of milk and soft cheese. International Dairy Journal, 16: 805-812.

Hurley, I.P., Coleman, R.C., Ireland, H.E. & Williams, J.H.H. (2004). Measurement of bovine IgG by indirect competitive ELISA as a means of detecting milk adulteration. Journal of Dairy Science, 87: 543-549.

Hurley, I.P., Ireland, H.E., Coleman, R.C., & Williams, J.H.H. (2004). Application of immunological methods for the detection of species adulteration in dairy products. International Journal of Food Science & Technology, 39: 873-878.

Ireland, H.E., Clutterbuck, A., Cloquet, J-P., Thurston, M.I. Williams, P.A., Cronk,Q.C., Dewey,F.M.  & Williams,J.H.H. (2004). The development of immunoassays to identify and quantify species source of gum arabic. Journal of Food and Agricultural Chemistry, 52: 7804-7808.

Ireland, H.E., Harding, S.J., Bonwick, G.A., Jones, M., Smith, C.J. & Williams, J.H.H. (2004). Evaluation of Hsp70 as a biomarker of environmental stress in Fucus serratus and Lemna minor. Biomarkers, 9: 139-155.

Pickles, N.A., Ireland, H.E., Al-Assaf, S. & Williams, J.H.H. (2004). Applications of Immunoassays in Hydrocolloid Research. In: Williams, P.A. & Philips, G.O. (Eds) Gums and Stabilisers for the Food Industry 12. Royal Society of Chemistry Publishers, Cambridge, UK. pp 317-327.


Conference Proceedings

Oral Presentation

H. Elyse Ireland. Anti-inflammatory properties of Hsp72 in the presence of HMGB-1. 8th World Congress on Trauma, Shock, Inflammation and Sepsis – TSIS2010, Munich, Germany. March 2010. *Recipient of a travel award as one of the top ten abstracts selected for the A.E. Baue Award session.

H. Elyse Ireland. Toll-like receptor 7 (TLR-7) is a candidate receptor for the anti-inflammatory properties of Hsp72. 8th World Congress on Trauma, Shock, Inflammation and Sepsis – TSIS2010, Munich, Germany. March 2010.

Elyse Ireland, Stephen Harding, Graham Bonwick, Mike Jones, Chris Smith & John Williams. Evaluation of Hsp70 as a biomarker of environmental stress in Fucus serratus and Lemna minor. First International Congress on Stress Responses in Biology and Medicine, Mount St. Anne, Québec, Canada. September 2003.

 

Poster Presentations

Helen Williams, H. Elyse Ireland & John H.H. Williams. Hsp72 activates macrophage differentiation and is a chemoattractant for leukocytes. 8th World Congress on Trauma, Shock, Inflammation and Sepsis – TSIS2010, Munich, Germany. March 2010.

H. Elyse Ireland, Christopher J. Smith & John H. H. Williams. A rapid ELISA for the detection of Hsp70 in plants. First International Congress on Stress Responses in Biology and Medicine, Mount St. Anne, Québec, Canada. September 2003.

Bonwick, G.A., Haines, J., Thurston, M., Ireland, H. E., Clutterbuck, A., Williams, P.A., Cronk, Q., Dewey, F.M., Patel, P.D. & Williams, J.H.H. Immunoassays for Gums. International Conference on Agri-Food Antibodies. Norwich. September 1999.

Williams, J.H.H., Jones, M. & Ireland, H. E. Protein-protein interactions during the heat shock response. International Congress on Stress of Life: Stress and Adaptation from Molecules to Man. Budapest, Hungary. June 1997.

Jones, M., Ireland, H. E. & Williams, J.H.H. Protein-protein interactions during the heat shock response. European Science Foundation Conference: Molecular Chaperones in Biology and Medicine. Strasbourg, France. May 1997.

Ireland, H. E. & Williams, J.H.H. Biomolecular interaction analysis of HSP70 interactions with partially denatured proteins. Plant Science Wales Meeting, Bangor. December 1996.

Williams, J.H.H., Albo,B., Ireland, H. E., Jones, M. & Smith, C.J. Protein-protein interactions involving HSP70. European Science Foundation International Conference: Biology of Molecular Chaperones. Aghia Pelaghia, Crete. September 1995.

Williams, J.H.H., Albo, B., Ireland, H. E., Jones, M. & Smith, C.J. Induction of mung bean HSP70 by exposure to high and low temperatures. EC Stressnet: Stress Physiology in Plants. Salsomaggiore, Italy. September 1995.

 

Reports

Williams, J. H. H. & Ireland, H. E. (2004). Identification of species origin of milk products using ELISA and PCR. Report for Food Standards Agency.

Ireland, H. E. & Williams, J. H. H. (2003). Validation of ELISAs for the detection and quantification of gums in foodstuffs.  Report for the period April 1999 to March 2001. Food Standards Agency.

Bonwick, G. A., Ireland, H. E. & Williams, J. H. H. (2001). Development of an immunoassay for gum Arabic (Acacia Senegal).  Report for the period July 1995 to March 1999. Food Standards Agency.