Chester Medical School Research Seminar Series

Posted on 23rd March 2015

The first of the Chester Medical School Lecture Series was delivered recently by Dr Gary Jones (Associate Professor, Department of Biology, National University of Ireland Maynooth, County Kildare, Ireland). His talk discussed the “Development of novel models to improve understanding of human diseases”

Yeast as a model for cancer and neurodegenerative diseases: new insights into the roles of protein chaperones in cell cycle control and amyloid formation.

Synopsis
Saccharomyces cerevisiae (baker's yeast) is a single-celled eukaryotic organism that is well established as a model for a variety of human diseases. This seminar will cover recent findings from studies focused on using yeast as a model for understanding the function of the ubiquitous Hsp70 chaperone within the cell. Specifically, this talk will describe i) a new role for Hsp70 in cell cycle control, a role that is conserved from yeast to humans and may offer potential for new therapeutic strategies for some cancers, and ii) the role of Hsp70 in propagating prions within yeast and how this relates to amyloid formation and propagation in humans.

References
Panaretou B and G. W. Jones (2014) Yeast models for amyloid diseases. Essays in Biochemistry 56:85-97.

Xu L, et al. (2013) Using steered molecular dynamics to predict and assess Hsp70 substrate- binding domain mutants that alter prion propagation. PLOS Computational Biology 9(1): e1002896.

Truman A. W, et al. (2012) CDK- dependent Hsp70 phosphorylation controls G1 cyclin abundance and cell cycle progression. Cell 151: 1308-1318.

Perrett S and G.W. Jones (2008) Insights into prion propagation. Current Opinion in Structural Biology 18(1): 52-9.